This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Vascular smooth muscle (VSM) cells, endothelial cells (EC), and pericytes that form the
walls of vessels in the microcirculation express a diverse array of ion channels that play an …

Magnetic-based systems utilizing superparamagnetic nanoparticles and a magnetic field
gradient to exert a force on these particles have been used in a wide range of biomedical …

Sustained increase in intraocular pressure represents a major risk factor for eye disease, yet
the cellular mechanisms of pressure transduction in the posterior eye are essentially …

Diabetes and hypertension are the leading causes of chronic kidney disease and their
incidence is increasing at an alarming rate. Both are associated with impairments in the …

The smooth muscle of arterioles responds to an increase in intraluminal pressure with
vasoconstriction and with vasodilation when pressure is decreased. Such myogenic …