The spleen is the largest secondary immune organ in the body and is responsible for
initiating immune reactions to blood-borne antigens and for filtering the blood of foreign …

While a complete blood count provides information regarding possible treatment-related
effects reflected in the peripheral blood, morphological evaluation of bone marrow cytology …

A rickettsia‐like organism (RLO) was isolated from infected coho salmon, Oncorhynchus
kisutch (Walbaum), in cultures from six fish cell lines, but could not be cultured on 41 artificial …

Extramedullary hematopoiesis (EMH) is the formation and development of blood cells
outside the medullary spaces of the bone marrow. Although widely considered an …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

Splenomegaly confirmed by surgery or necropsy in 100 dogs was diagnosed histologically
as benign neoplasia (n= 1), primary splenic malignancy (n= 59), neoplastic metastases (n …

During the past 20 years the EU legislation for the notification of chemicals has focussed on
new chemicals and at the same time failed to cover the evaluation of existing chemicals in …

As a major hematopoietic and lymphoid organ, morphological evaluation of the bone
marrow is an important component of toxicity or safety assessment studies. While definitive …

This manuscript is intended to provide a best practice approach to accurately and
consistently assess toxicant-induced bone marrow effects of test articles. In nonclinical …

Dogs and cats are the animals that owners most frequently seek assistance for potential
poisonings, and these species are frequently involved with toxicoses due to ingestion of …