Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Both inflammasomes and autophagy have important roles in the intracellular homeostasis,
inflammation, and pathology; the dysregulation of these processes is often associated with …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

Autophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and
survival of the cell in the face of stressors as different as starvation, infection, or protein …

Autophagy, a main intracellular catabolic process, is induced in response to a variety of
cellular stresses to promptly degrade harmful agents and to coordinate the activity of …

Highlights•TRIM proteins are E3 ubiquitin ligases that target specific substrates.•TRIM
proteins regulate antiviral cytokine induction or autophagy.•Several TRIM proteins directly …

Background: Pathological cardiac hypertrophy is one of the leading causes of heart failure
with highly complicated pathogeneses. The E3 ligase TRIM16 (tripartite motif–containing …

Doxorubicin (DOX) is a most common anthracycline chemotherapeutic agent; however, its
clinical efficacy is limited due to its severe and irreversible cardiotoxicity. Ferroptosis …

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …