The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Protein folding is inherently error prone, especially in the endoplasmic reticulum (ER). Even
with an elaborate network of molecular chaperones and protein folding facilitators …

The covalent conjugation of ubiquitin family proteins is a widespread post-translational
protein modification. In the ubiquitin family, the ATG8 subfamily is exceptional because it is …

Protein homeostasis mechanisms are fundamentally important to match cellular needs and
to counteract stress conditions. A fundamental challenge is to understand how defective …

The covalent attachment of ubiquitin is a common regulatory mechanism in various proteins.
Although it has long been thought that the substrates of ubiquitination are limited to proteins …

Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate
essential cellular activities including protein quality control, calcium flux, and sterol …

To date, cross-species comparisons of genetic interactomes have been restricted to small or
functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a …

Cellular homeostasis requires the ubiquitin‐dependent degradation of membrane proteins.
This was assumed to be mediated exclusively either by endoplasmic reticulum‐associated …

Sterols are a major component of eukaryotic cell membranes. For human fungal infections
caused by the filamentous fungus Aspergillus fumigatus, antifungal drugs that target sterol …

Background Hepatocellular carcinoma (HCC) is one of the most malignant tumors and the
fourth leading cause of cancer-related death worldwide. Sorafenib is currently …