Proteome-scale interaction prediction is essential for understanding protein functions and
disease mechanisms. Traditional experimental methods are often limited by scale and …

Progress in biology has generated numerous lists of genes that share some property. But
advancing from these lists of genes to understanding their roles is slow and unsystematic …

In this study we employed a data-driven approach to explore the evolutionary and genetic
determinants of protein direct interactions and stable complex formation in the human …

Natural transformation (NT) represents one of the major modes of horizontal gene transfer in
bacterial species. During NT, cells can take up free DNA from the environment and integrate …

Protein-protein interactions are essential for numerous biological functions, and predicting
binding affinity changes caused by mutations is crucial for understanding the impact of …

Protein structure and protein-protein interaction (PPI) predictions based on coevolution have
transformed structural biology, but managing pre-processing and post-processing can be …