Segregation of the replicated genome during cell division in eukaryotes requires the
kinetochore to link centromeric DNA to spindle microtubules. The kinetochore is composed …

The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the
most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as …

Kinetochores play an essential role in chromosome segregation by forming dynamic
connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore …

The mechanisms that specify precisely where mammalian kinetochores form within arrays of
centromeric heterochromatin remain largely unknown. Localization of CENP-A exclusively …

The mitotic checkpoint ensures that chromosomes are divided equally between daughter
cells and is a primary mechanism preventing the chromosome instability often seen in …

The molecular motor dynein concentrates at the kinetochore region of mitotic chromosomes
in animals to accelerate spindle microtubule capture and to control spindle checkpoint …

Defects in kinetochore proteins often lead to aneuploidy and cancer. Mis12–Mtw1 is a
conserved, essential kinetochore protein family. Here, we show that a Mis12 core complex …

The spindle checkpoint assures the proper segregation of chromosomes during mitosis. The
best-characterized components of the checkpoint were originally identified in budding yeast …

Androgen receptor (AR) is overexpressed in the majority of castration-resistant prostate
cancers (CRPCs). Our goal was to study the effect of AR overexpression on the chromatin …

Successful completion of mitosis requires that sister kinetochores become attached end-on
to the plus ends of spindle microtubules (MTs) in prometaphase, thereby forming …