[HTML][HTML] Diverse functions of the prion protein–Does proteolytic processing hold the key?
L Linsenmeier, HC Altmeppen, S Wetzel… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Proteolytic processing of the cellular and disease-associated form of the prion protein leads
to generation of bioactive soluble prion protein fragments and modifies the structure and …
to generation of bioactive soluble prion protein fragments and modifies the structure and …
Prions: beyond a single protein
AS Das, WQ Zou - Clinical microbiology reviews, 2016 - Am Soc Microbiol
Since the term protein was first coined in 1838 and protein was discovered to be the
essential component of fibrin and albumin, all cellular proteins were presumed to play …
essential component of fibrin and albumin, all cellular proteins were presumed to play …
Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease
CD Orrú, J Yuan, BS Appleby, B Li, Y Li… - Science translational …, 2017 - science.org
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
transmissible through iatrogenic routes due to abundant infectious prions [misfolded forms of …
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies
The prion protein (PrPC) is a central player in neurodegenerative diseases, such as prion
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …
diseases or Alzheimer's disease. In contrast to disease-promoting cell surface PrPC …
The sheddase ADAM10 is a potent modulator of prion disease
The prion protein (PrPC) is highly expressed in the nervous system and critically involved in
prion diseases where it misfolds into pathogenic PrPSc. Moreover, it has been suggested as …
prion diseases where it misfolds into pathogenic PrPSc. Moreover, it has been suggested as …
Early preclinical detection of prions in the skin of prion-infected animals
A definitive pre-mortem diagnosis of prion disease depends on brain biopsy for prion
detection currently and no validated alternative preclinical diagnostic tests have been …
detection currently and no validated alternative preclinical diagnostic tests have been …
Post hoc support vector machine learning for impedimetric biosensors based on weak protein–ligand interactions
Impedimetric biosensors for measuring small molecules based on weak/transient
interactions between bioreceptors and target analytes are a challenge for detection …
interactions between bioreceptors and target analytes are a challenge for detection …
Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy
A Otero, T Barrio, H Eraña, JM Charco… - PLoS …, 2022 - journals.plos.org
The role of the glycosylation status of PrPC in the conversion to its pathological counterpart
and on cross-species transmission of prion strains has been widely discussed. Here, we …
and on cross-species transmission of prion strains has been widely discussed. Here, we …
Decrease in skin prion-seeding activity of prion-infected mice treated with a compound against human and animal prions: a first possible biomarker for prion …
M Ding, K Teruya, W Zhang, HW Lee, J Yuan… - Molecular …, 2021 - Springer
Previous studies have revealed that the infectious scrapie isoform of prion protein (PrPSc)
harbored in the skin tissue of patients or animals with prion diseases can be amplified and …
harbored in the skin tissue of patients or animals with prion diseases can be amplified and …
In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding
Prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of rare
progressive neurodegenerative disorders caused by an abnormally folded prion protein …
progressive neurodegenerative disorders caused by an abnormally folded prion protein …