Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …

Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one
etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy …

Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …

Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …

A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

A fundamental question in cell biology, under investigation for over six decades, is the
structural organization of mitochondrial cristae. Long known to harbor electron transport …

The haploinsufficiency of C9orf72 is implicated in the most common forms of amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the full spectrum of C9orf72 …

Low levels of reactive oxygen species (ROS) are crucial for maintaining cancer stem cells
(CSCs) and their ability to resist therapy, but the ROS regulatory mechanisms in CSCs …

Abnormal mitochondrial fission participates in the pathogenesis of many diseases. Long non-
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …