[HTML][HTML] Quality control of the mitochondrion
Mitochondria are essential organelles that execute and coordinate various metabolic
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
processes in the cell. Mitochondrial dysfunction severely affects cell fitness and contributes …
Lipids of mitochondria
SE Horvath, G Daum - Progress in lipid research, 2013 - Elsevier
A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are
susceptible to senescence during aging. We demonstrate the importance of the amount of …
susceptible to senescence during aging. We demonstrate the importance of the amount of …
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
Insights from inherited forms of parkinsonism suggest that insufficient mitophagy may be one
etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy …
etiology of the disease. PINK1/Parkin-dependent mitophagy, which helps maintain a healthy …
The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …
major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a …
Making heads or tails of phospholipids in mitochondria
Mitochondria are dynamic organelles whose functional integrity requires a coordinated
supply of proteins and phospholipids. Defined functions of specific phospholipids, like the …
supply of proteins and phospholipids. Defined functions of specific phospholipids, like the …
CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation
K Wang, BO Long, LY Zhou, F Liu, QY Zhou… - Nature …, 2014 - nature.com
Abnormal mitochondrial fission participates in the pathogenesis of many diseases. Long non-
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …
coding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs …
[HTML][HTML] Cardiolipin and mitochondrial cristae organization
A fundamental question in cell biology, under investigation for over six decades, is the
structural organization of mitochondrial cristae. Long known to harbor electron transport …
structural organization of mitochondrial cristae. Long known to harbor electron transport …
[HTML][HTML] Mitochondria: the next (neurode) generation
EA Schon, S Przedborski - Neuron, 2011 - cell.com
Adult-onset neurodegenerative disorders are disabling and often fatal diseases of the
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …
nervous system whose underlying mechanisms of cell death remain unknown. Defects in …
[HTML][HTML] C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly
The haploinsufficiency of C9orf72 is implicated in the most common forms of amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the full spectrum of C9orf72 …
lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the full spectrum of C9orf72 …