Streptococcus pneumoniae: transmission, colonization and invasion

JN Weiser, DM Ferreira, JC Paton - Nature Reviews Microbiology, 2018 - nature.com
Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

Transporters of glucose and other carbohydrates in bacteria

JM Jeckelmann, B Erni - Pflügers Archiv-European Journal of Physiology, 2020 - Springer
Glucose arguably is the most important energy carrier, carbon source for metabolites and
building block for biopolymers in all kingdoms of life. The proper function of animal organs …

Elucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut

A Bell, J Brunt, E Crost, L Vaux, R Nepravishta… - Nature …, 2019 - nature.com
Sialic acid (N-acetylneuraminic acid (Neu5Ac)) is commonly found in the terminal location of
colonic mucin glycans where it is a much-coveted nutrient for gut bacteria, including …

Absorption, metabolism, and functions of hyaluronic acid and its therapeutic prospects in combination with microorganisms: A review

X Zheng, B Wang, X Tang, B Mao, Q Zhang… - Carbohydrate …, 2023 - Elsevier
Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

AS Manso, MH Chai, JM Atack, L Furi… - Nature …, 2014 - nature.com
Streptococcus pneumoniae (the pneumococcus) is the world's foremost bacterial pathogen
in both morbidity and mortality. Switching between phenotypic forms (or 'phases') that favour …

PanOCT: automated clustering of orthologs using conserved gene neighborhood for pan-genomic analysis of bacterial strains and closely related species

DE Fouts, L Brinkac, E Beck, J Inman… - Nucleic acids …, 2012 - academic.oup.com
Pan-genome ortholog clustering tool (PanOCT) is a tool for pan-genomic analysis of closely
related prokaryotic species or strains. PanOCT uses conserved gene neighborhood …

Fueling the caries process: carbohydrate metabolism and gene regulation by Streptococcus mutans

ZD Moye, L Zeng, RA Burne - Journal of oral microbiology, 2014 - Taylor & Francis
The nature of the oral cavity and host behaviors has mandated that the oral microbiota
evolve mechanisms for co** with environmental fluctuations, especially changes in the …

High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions

R Aprianto, J Slager, S Holsappel… - Nucleic acids …, 2018 - academic.oup.com
Streptococcus pneumoniae is an opportunistic human pathogen that typically colonizes the
nasopharyngeal passage and causes lethal disease in other host niches, such as the lung …

A visual review of the human pathogen Streptococcus pneumoniae

DH Engholm, M Kilian, DS Goodsell… - FEMS microbiology …, 2017 - academic.oup.com
Being the principal causative agent of bacterial pneumonia, otitis media, meningitis and
septicemia, the bacterium Streptococcus pneumoniae is a major global health problem. To …

Time-resolved dual RNA-seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection

R Aprianto, J Slager, S Holsappel, JW Veening - Genome biology, 2016 - Springer
Background Streptococcus pneumoniae, the pneumococcus, is the main etiological agent of
pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …