[HTML][HTML] Molecular mechanisms of stress granule assembly and disassembly

S Hofmann, N Kedersha, P Anderson… - Biochimica et Biophysica …, 2021 - Elsevier
Stress granules (SGs) are membrane-less ribonucleoprotein (RNP)-based cellular
compartments that form in the cytoplasm of a cell upon exposure to various environmental …

Stress granules and processing bodies in translational control

P Ivanov, N Kedersha… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA
granules that dynamically sequester translationally inactive messenger ribonucleoprotein …

Mechanistic insights into mammalian stress granule dynamics

MD Panas, P Ivanov, P Anderson - Journal of Cell Biology, 2016 - rupress.org
The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

[HTML][HTML] Modulation of RNA condensation by the DEAD-box protein eIF4A

D Tauber, G Tauber, A Khong, B Van Treeck, J Pelletier… - Cell, 2020 - cell.com
Stress granules are condensates of non-translating mRNAs and proteins involved in the
stress response and neurodegenerative diseases. Stress granules form in part through …

Mechanisms and regulation of RNA condensation in RNP granule formation

D Tauber, G Tauber, R Parker - Trends in biochemical sciences, 2020 - cell.com
Ribonucleoprotein (RNP) granules are RNA–protein assemblies that are involved in
multiple aspects of RNA metabolism and are linked to memory, development, and disease …

From unwinding to clam**—the DEAD box RNA helicase family

P Linder, E Jankowsky - Nature reviews Molecular cell biology, 2011 - nature.com
RNA helicases of the DEAD box family are present in all eukaryotic cells and in many
bacteria and Archaea. These highly conserved enzymes are required for RNA metabolism …

Stress granules, P-bodies and cancer

P Anderson, N Kedersha, P Ivanov - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
Cancer cells are exposed to adverse conditions in the tumor microenvironment, and utilize
post-transcriptional control mechanisms to re-program gene expression in ways that …

Decoding human cytomegalovirus

N Stern-Ginossar, B Weisburd, A Michalski, VTK Le… - Science, 2012 - science.org
The human cytomegalovirus (HCMV) genome was sequenced 20 years ago. However, like
those of other complex viruses, our understanding of its protein coding potential is far from …

[HTML][HTML] Regulation of translation initiation in eukaryotes: mechanisms and biological targets

N Sonenberg, AG Hinnebusch - Cell, 2009 - cell.com
Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development

J Pelletier, J Graff, D Ruggero, N Sonenberg - Cancer research, 2015 - AACR
Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …