Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs
L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …
is currently a major hurdle in bringing new drug molecules to the market. According to some …
Delivering on the promise of protein degraders
Over the past 3 years, the first bivalent protein degraders intentionally designed for targeted
protein degradation (TPD) have advanced to clinical trials, with an initial focus on …
protein degradation (TPD) have advanced to clinical trials, with an initial focus on …
[HTML][HTML] Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population
S Salunke, F O'Brien, DCT Tan, D Harris… - Advanced Drug Delivery …, 2022 - Elsevier
Selecting the appropriate formulation and solubility-enabling technology for poorly water
soluble drugs is an essential element in the development of formulations for paediatric …
soluble drugs is an essential element in the development of formulations for paediatric …
[HTML][HTML] Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug
Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and
facilitate the noninvasive transdermal delivery of many hydrophilic substances. However …
facilitate the noninvasive transdermal delivery of many hydrophilic substances. However …
Advances in lipid-based carriers for cancer therapeutics: Liposomes, exosomes and hybrid exosomes
Cancer has recently surpassed heart disease as the leading cause of deaths worldwide for
the age group 45–65 and has been the primary focus for biomedical researchers. Presently …
the age group 45–65 and has been the primary focus for biomedical researchers. Presently …
Strategies for oral delivery of bioactive peptides with focus on debittering and masking
Protein hydrolysis is a process used in the food industry to generate bioactive peptides of
low molecular weight and with additional health benefits, such as antihypertensive …
low molecular weight and with additional health benefits, such as antihypertensive …
Current trends on solid dispersions: past, present, and future
R Malkawi, WI Malkawi, Y Al-Mahmoud… - Advances in …, 2022 - Wiley Online Library
Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …
[PDF][PDF] RETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer …
Abstract We, the Editors and Publisher of Drug Delivery have retracted the following article:
Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Mohammad A. Altamimi, Nabil K …
Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Mohammad A. Altamimi, Nabil K …
Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development
R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
absorption leading to poor bioavailability. Several approaches exist that improve the oral …
Microarray patches: poking a hole in the challenges faced when delivering poorly soluble drugs
Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …