Two opposing models have been proposed to describe the function of the MYC oncoprotein
in sha** cellular transcriptomes: one posits that MYC amplifies transcription at all active …

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

Transfer RNA-derived fragments (tRFs) are emerging small noncoding RNAs that, although
commonly altered in cancer, have poorly defined roles in tumorigenesis. Here we show that …

MicroRNAs (miRNAs) are small noncoding RNAs that extensively regulate gene expression
in animals, plants, and protozoa. miRNAs function posttranscriptionally by usually base …

Translational control in eukaryotic cells is critical for gene regulation during nutrient
deprivation and stress, development and differentiation, nervous system function, aging, and …

Remarkable progress has been made in defining a new understanding of the role of mRNA
translation and protein synthesis in human cancer. Translational control is a crucial …

Structures of the bacterial ribosome have provided a framework for understanding universal
mechanisms of protein synthesis. However, the eukaryotic ribosome is much larger than it is …

Mechanisms of implantation such as determination of the attachment pole, fetal-maternal
communication, and underlying causes of implantation failure are largely unexplored. Here …

MicroRNAs (miRNAs) are 20-nt-long to 24-nt-long noncoding RNAs acting as post-
transcriptional regulators of gene expression in animals and plants. In mammals, more than …

Elucidating the molecular drivers of human breast cancers requires a strategy that is
capable of integrating multiple forms of data and an ability to interpret the functional …