Material-binding peptides (MBPs) have emerged as a diverse and innovation-enabling class
of peptides in applications such as plant-/human health, immobilization of catalysts …

Enzymes as catalysts in synthetic organic chemistry gained importance in the latter half of
the 20th century, but nevertheless suffered from two major limitations. First, many enzymes …

Directed evolution has advanced into a standard industrial “tool” to tailor naturally occurring
proteins for a variety of biotechnological applications, thus enabling product valorization and …

Abstract In 1989, Manning, Patel, and Borchardt wrote a review of protein stability (Manning
et al., Pharm. Res. 6: 903–918, 1989), which has been widely referenced ever since. At the …

Saturation mutagenesis probes define sections of the vast protein sequence space.
However, even if randomization is limited this way, the combinatorial numbers problem is …

Asymmetric catalysis plays a key role in modern synthetic organic chemistry, with synthetic
catalysts and enzymes being the two available options. During the latter part of the last …

Metabolic engineering for the overproduction of high-value small molecules is dependent
upon techniques in directed evolution to improve production titers. The majority of small …

Continued advances in metabolic engineering are increasing the number of small
molecules being targeted for microbial production. Pathway yields and productivities …

Of more than 200,000 plant natural products known to date, many demonstrate important
pharmacological activities or are of biotechnological significance. However, isolation from …

Lignocellulosic biomass is a most promising feedstock in the production of second-
generation biofuels. Efficient degradation of lignocellulosic biomass requires a synergistic …