Objective To improve the use of N-of-1 studies in rare genetic neurodevelopmental
disorders, we systematically reviewed the literature and formulated recommendations for …

Although cannabis-based products for medicinal use are now legal in the UK, it is still
challenging for patients to gain access, and only very few National Health Service …

Objectives To describe, and explain the rationale for, the methods used and decisions made
during development of the updated SPIRIT 2024 and CONSORT 2024 reporting guidelines …

Abstract 'Individualized therapy'trials (sometimes called n-of-1 trials) use patients as their
own controls to evaluate treatments. Here we divide such trials into three categories: multi …

Current nutritional and genetic epidemiological methods yield 'risk factors' on the basis of
population studies. Risk factors, however, are statistical estimates of the percentage …

SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013 provides
guidance for clinical trial protocol writing. However, neither the original guidance nor its …

Background Individuals exhibit fluctuations in the concentration of serum thyroid-stimulating
hormone (TSH) over time. The scale of these variations ranges from minutes to hours, and …

Due to the complex nature of single-case experimental design data, numerous effect
measures are available to quantify and evaluate the effectiveness of an intervention. An …

Summary The 2013 SPIRIT (Standard Protocol Items: Recommendations for Interventional
Trials) Statement provides evidence-based recommendations for the minimum content to be …

Abstract Background and Aims Heterogeneity of treatment effects in inflammatory bowel
disease means that many individuals or patient subgroups depart from the average for …