Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes
Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …
[HTML][HTML] GLP-1 and GIP receptor signaling in beta cells–a review of receptor interactions and co-stimulation
Glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
polypeptide receptor (GIPR) are two class B1 G protein-coupled receptors, which are …
Protective role of IGF-1 and GLP-1 signaling activation in neurological dysfunctions
Abstract Insulin-like growth factor-1 (IGF-1), a pleiotropic polypeptide, plays an essential role
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
in CNS development and maturation. Glucagon-like peptide-1 (GLP-1) is an endogenous …
cAMP signalling in insulin and glucagon secretion
A Tengholm, E Gylfe - Diabetes, obesity and metabolism, 2017 - Wiley Online Library
The “second messenger” archetype cAMP is one of the most important cellular signalling
molecules with central functions including the regulation of insulin and glucagon secretion …
molecules with central functions including the regulation of insulin and glucagon secretion …
Intracellular cAMP sensor EPAC: physiology, pathophysiology, and therapeutics development
WG Robichaux III, X Cheng - Physiological reviews, 2018 - journals.physiology.org
This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …
Mechanisms of action of glucagon-like peptide 1 in the pancreas
ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …
Regulation of glucose homeostasis by GLP-1
P Nadkarni, OG Chepurny, GG Holz - Progress in molecular biology and …, 2014 - Elsevier
Abstract Glucagon-like peptide-1 (7–36) amide (GLP-1) is a secreted peptide that acts as a
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
key determinant of blood glucose homeostasis by virtue of its abilities to slow gastric …
Epac: defining a new mechanism for cAMP action
M Gloerich, JL Bos - Annual review of pharmacology and …, 2010 - annualreviews.org
cAMP is a second messenger that is essential for relaying hormonal responses in many
biological processes. The discovery of the cAMP target Epac explained various effects of …
biological processes. The discovery of the cAMP target Epac explained various effects of …
Epac proteins: multi-purpose cAMP targets
JL Bos - Trends in biochemical sciences, 2006 - cell.com
Epac1 and Epac2 are cAMP-dependent guanine-nucleotide-exchange factors for the small
GTPases Rap1 and Rap2, and are known to be important mediators of cAMP signaling. The …
GTPases Rap1 and Rap2, and are known to be important mediators of cAMP signaling. The …