Apoptotic cell death in disease—Current understanding of the NCCD 2023
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …
The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers
Z Sondka, S Bamford, CG Cole, SA Ward… - Nature Reviews …, 2018 - nature.com
Abstract The Catalogue of Somatic Mutations in Cancer (COSMIC) Cancer Gene Census
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …
(CGC) is an expert-curated description of the genes driving human cancer that is used as a …
[HTML][HTML] Ovarian cancer development and metastasis
E Lengyel - The American journal of pathology, 2010 - Elsevier
The biology of ovarian carcinoma differs from that of hematogenously metastasizing tumors
because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only …
because ovarian cancer cells primarily disseminate within the peritoneal cavity and are only …
[HTML][HTML] Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Cancer cell genetic variability and similarity to host cells have stymied development of broad
anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse …
anti-cancer therapeutics. Our innate immune system evolved to clear genetically diverse …
The TNF family of ligands and receptors: communication modules in the immune system and beyond
The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF)
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
include 19 ligands and 29 receptors that play important roles in the modulation of cellular …
A fate worse than death: apoptosis as an oncogenic process
Apoptotic cell death is widely considered a positive process that both prevents and treats
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …
cancer. Although undoubtedly having a beneficial role, paradoxically, apoptosis can also …
A critical role for Fas-mediated off-target tumor killing in T-cell immunotherapy
R Upadhyay, JA Boiarsky, G Pantsulaia… - Cancer discovery, 2021 - AACR
T cell–based therapies have induced cancer remissions, though most tumors ultimately
progress, reflecting inherent or acquired resistance including antigen escape. Better …
progress, reflecting inherent or acquired resistance including antigen escape. Better …
The role of lipid metabolism in aging, lifespan regulation, and age‐related disease
An emerging body of data suggests that lipid metabolism has an important role to play in the
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
aging process. Indeed, a plethora of dietary, pharmacological, genetic, and surgical lipid …
Regulated cell death and inflammation: an auto-amplification loop causes organ failure
Regulated cell death (RCD) is either immunologically silent or immunogenic. RCD in
parenchymal cells may lead to the release of damage-associated molecular patterns that …
parenchymal cells may lead to the release of damage-associated molecular patterns that …
The role of CD95 and CD95 ligand in cancer
Abstract CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death
receptor/death ligand system that mediates apoptosis induction to maintain immune …
receptor/death ligand system that mediates apoptosis induction to maintain immune …