RNA-based therapeutics: an overview and prospectus

Y Zhu, L Zhu, X Wang, H ** - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …

Recent progress of SELEX methods for screening nucleic acid aptamers

C Zhu, Z Feng, H Qin, L Chen, M Yan, L Li, F Qu - Talanta, 2024 - Elsevier
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …

Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations

LF Yang, M Ling, N Kacherovsky, SH Pun - Chemical science, 2023 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …

Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development

H Yu, O Alkhamis, J Canoura, Y Liu… - Angewandte Chemie …, 2021 - Wiley Online Library
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …

Aptamers as targeted therapeutics: current potential and challenges

J Zhou, J Rossi - Nature reviews Drug discovery, 2017 - nature.com
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …

[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development

T Wang, C Chen, LM Larcher, RA Barrero… - Biotechnology …, 2019 - Elsevier
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …

Recent advances in SELEX technology and aptamer applications in biomedicine

Z Zhuo, Y Yu, M Wang, J Li, Z Zhang, J Liu… - International journal of …, 2017 - mdpi.com
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with
high affinity and specificity. The process of selecting an aptamer is called Systematic …

SELEX: Critical factors and optimization strategies for successful aptamer selection

M Kohlberger, G Gadermaier - Biotechnology and applied …, 2022 - Wiley Online Library
Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …

Aptamers as therapeutics

SM Nimjee, RR White, RC Becker… - Annual review of …, 2017 - annualreviews.org
Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and
are commonly produced by systematic evolution of ligands by exponential enrichment …

Application of aptamers in virus detection and antiviral therapy

X Zou, J Wu, J Gu, L Shen, L Mao - Frontiers in microbiology, 2019 - frontiersin.org
Viral infections can cause serious diseases for humans and animals. Accurate and early
detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly …