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RNA-based therapeutics: an overview and prospectus
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …
the application of various RNAs to selectively function on hitherto “undruggable” proteins …
Recent progress of SELEX methods for screening nucleic acid aptamers
C Zhu, Z Feng, H Qin, L Chen, M Yan, L Li, F Qu - Talanta, 2024 - Elsevier
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …
Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations
Aptamers are single-stranded nucleic acids that bind and recognize targets much like
antibodies. Recently, aptamers have garnered increased interest due to their unique …
antibodies. Recently, aptamers have garnered increased interest due to their unique …
Advances and challenges in small‐molecule DNA aptamer isolation, characterization, and sensor development
Aptamers are short oligonucleotides isolated in vitro from randomized libraries that can bind
to specific molecules with high affinity, and offer a number of advantages relative to …
to specific molecules with high affinity, and offer a number of advantages relative to …
Aptamers as targeted therapeutics: current potential and challenges
Nucleic acid aptamers, often termed'chemical antibodies', are functionally comparable to
traditional antibodies, but offer several advantages, including their relatively small physical …
traditional antibodies, but offer several advantages, including their relatively small physical …
[HTML][HTML] Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development
Aptamers are short single-stranded nucleic acid sequences capable of binding to target
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
molecules in a way similar to antibodies. Due to various advantages such as prolonged …
Recent advances in SELEX technology and aptamer applications in biomedicine
Z Zhuo, Y Yu, M Wang, J Li, Z Zhang, J Liu… - International journal of …, 2017 - mdpi.com
Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with
high affinity and specificity. The process of selecting an aptamer is called Systematic …
high affinity and specificity. The process of selecting an aptamer is called Systematic …
SELEX: Critical factors and optimization strategies for successful aptamer selection
Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …
Aptamers as therapeutics
Aptamers are single-stranded nucleic acid molecules that bind to and inhibit proteins and
are commonly produced by systematic evolution of ligands by exponential enrichment …
are commonly produced by systematic evolution of ligands by exponential enrichment …
Application of aptamers in virus detection and antiviral therapy
X Zou, J Wu, J Gu, L Shen, L Mao - Frontiers in microbiology, 2019 - frontiersin.org
Viral infections can cause serious diseases for humans and animals. Accurate and early
detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly …
detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly …