Calcium-independent phospholipases A2 and their roles in biological processes and diseases

S Ramanadham, T Ali, JW Ashley, RN Bone… - Journal of lipid …, 2015 - ASBMB
Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia

M Peet, J Brind, CN Ramchand, S Shah… - Schizophrenia research, 2001 - Elsevier
Evidence that the metabolism of phospholipids and polyunsaturated fatty acids (PUFA) is
abnormal in schizophrenia provided the rationale for intervention studies using PUFA …

Text mining: generating hypotheses from MEDLINE

P Srinivasan - Journal of the American Society for Information …, 2004 - Wiley Online Library
Hypothesis generation, a crucial initial step for making scientific discoveries, relies on prior
knowledge, experience, and intuition. Chance connections made between seemingly …

Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia

WS Fenton, J Hibbeln, M Knable - Biological psychiatry, 2000 - Elsevier
Recent research suggests that deficient uptake or excessive breakdown of membrane
phospholipids may be associated with schizophrenia. We review available clinical research …

A dose-ranging exploratory study of the effects of ethyl-eicosapentaenoate in patients with persistent schizophrenic symptoms

M Peet, DF Horrobin… - Journal of psychiatric …, 2002 - Elsevier
The objective was to test effects of ethyl eicosapentaenoate (EE) on persistent ongoing
symptoms in patients receiving different types of anti-schizophrenic drugs, typical …

The energy metabolism dysfunction in psychiatric disorders postmortem brains: focus on proteomic evidence

GS Zuccoli, VM Saia-Cereda, JM Nascimento… - Frontiers in …, 2017 - frontiersin.org
Psychiatric disorders represent a great medical and social challenge and people suffering
from these conditions face many impairments regarding personal and professional life. In …

Beneficial effect (s) of n-3 fatty acids in cardiovascular diseases: but, why and how?

UN Das - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2000 - Elsevier
Low rates of coronary heart disease was found in Greenland Eskimos and Japanese who
are exposed to a diet rich in fish oil. Suggested mechanisms for this cardio-protective effect …

Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in schizophrenia

SP Mahadik, D Evans, H Lal - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
Oxidative stress and role of antioxidant and ω-3 essential fatty acid supplementation in
schizophrenia - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

Using ARROWSMITH: a computer-assisted approach to formulating and assessing scientific hypotheses

NR Smalheiser, DR Swanson - Computer methods and programs in …, 1998 - Elsevier
Conventional computer searches of the biomedical literature (eg MEDLINE) allow
investigators to retrieve much of the information that has already been published on a given …

Depression and bipolar disorder: relationships to impaired fatty acid and phospholipid metabolism and to diabetes, cardiovascular disease, immunological …

DF Horrobin, CN Bennett - … , Leukotrienes and Essential Fatty Acids (PLEFA), 1999 - Elsevier
Depression and bipolar disorder are two of the commonest illnesses in the developed world.
While some patients can be treated effectively with available drugs, many do not respond …