Objectives Glioma is one of the most aggressive brain tumours with poor overall survival
despite advanced technology in surgical resection, chemotherapy and radiation …

Background: Cancer can be considered as a genetic as well as a metabolic disorder. The
current cancer treatment scenario looks like aggravating tumor cell metabolism, causing the …

The hybrid heterocyclic molecules are perspective materials in the development of
anticancer drugs. Here, the pyrrolidinedione-thiazolidinone hybrid molecules were designed …

The aim of the present study was to investigate the antiproliferative and proapoptotic actions
of N-(5-benzyl-1, 3-thiazol-2-yl)-3, 5-dimethyl-1-benzofuran-2-carboxamide derivative …

thiazolidinones, which are privileged structures in medicinal chemistry, comprise the well-
known class of heterocycles and are a source of new drug-like compounds. Undoubtedly …

The controlled delivery of anticancer drugs is driven by their interaction with carrier
molecules. By creating complicated micelle-like complexes, amphiphilic polymers provide …

Following of the chemical diversity of 4-thiazolidinones the in-house library of new
heterocycles have been designed and synthesized (more 7000 compounds). Anticancer …

Purpose Our study aimed to assess the effects of anticancer 4-thiazolidinone-based free
water-insoluble therapeutics Les-3288 and Les-3833 and their waterborne complexes with …

PPARγ regulate the expression of genes involved in peripheral insulin sensitivity,
adipogenesis, and glucose homeostasis. Moreover, PPARγ agonists, such as pioglitazone …

Nephrotoxicity is a significant side effect of doxorubicin (DXN) treatment. We investigated the
protective effect of gemfibrozil (GEM) co-administration with DXN on DXN induced …