Assessment of glyphosate induced epigenetic transgenerational inheritance of pathologies and sperm epimutations: generational toxicology

D Kubsad, EE Nilsson, SE King, I Sadler-Riggleman… - Scientific reports, 2019 - nature.com
Ancestral environmental exposures to a variety of factors and toxicants have been shown to
promote the epigenetic transgenerational inheritance of adult onset disease. One of the …

Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation

P Sampedro-Piquero, DL de Guevara-Miranda… - Neuroscience & …, 2019 - Elsevier
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure
compromises brain neuroplasticity. Brain areas normally involved in learning and goal …

Brain and cognition for addiction medicine: From prevention to recovery neural substrates for treatment of psychostimulant-induced cognitive deficits

MS D'Souza - Frontiers in psychiatry, 2019 - frontiersin.org
Addiction to psychostimulants like cocaine, methamphetamine, and nicotine poses a
continuing medical and social challenge both in the United States and all over the world …

[HTML][HTML] Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice

JC Ledesma, C Manzanedo, MA Aguilar - Progress in Neuro …, 2021 - Elsevier
Cocaine dependence is a highly prevalent disease in modern society and lacks an effective
treatment. Cannabidiol (CBD), a major non-psychoactive constituent of Cannabis sativa, has …

Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior

V Deroche-Gamonet, JM Revest, JF Fiancette… - Molecular …, 2019 - nature.com
The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of
studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric …

Lysophosphatidic acid‐induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine‐contextual memory

D Ladrón de Guevara‐Miranda… - Addiction …, 2019 - Wiley Online Library
Erasing memories of cocaine–stimuli associations might have important clinical implications
for addiction therapy. Stimulating hippocampal plasticity by enhancing adult hippocampal …

Bioelectronic medicine: a multidisciplinary roadmap from biophysics to precision therapies

MA González-González, SV Conde… - Frontiers in Integrative …, 2024 - frontiersin.org
Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive
clinical benefits, alongside unique challenges. It consists of the modulation of the nervous …

A functional pipeline of genome-wide association data leads to midostaurin as a repurposed drug for Alzheimer's disease

A Esteban-Martos, AM Brokate-Llanos… - International Journal of …, 2023 - mdpi.com
Genome-wide association studies (GWAS) constitute a powerful tool to identify the different
biochemical pathways associated with disease. This knowledge can be used to prioritize …

Impaired decision making following escalation of cocaine self‐administration predicts vulnerability to relapse in rats

PJ Cocker, JY Rotge, ML Daniel… - Addiction …, 2020 - Wiley Online Library
Impairments in cost‐benefit decision making represent a cardinal feature of drug addiction.
However, whether these alterations predate drug exposure, thereby contributing to …

Social rank-associated stress vulnerability predisposes individuals to cocaine attraction

C Yanovich, ML Kirby, I Michaelevski, G Yadid… - Scientific reports, 2018 - nature.com
Studies of personality have suggested that dissimilarities in ability to cope with stressful
situations results in differing tendency to develop addictive behaviors. The present study …