Abstract EWSR1-CREB1 and EWSR1-ATF1 are gene fusions of which one or both have
now been consistently described in 5 histopathologically and behaviorally diverse …

Many soft tissue sarcomas have chromosomal translocations with resultant formation of new
fusion genes. Among the genes that can be rearranged, the EWSR 1 gene has been …

Oncogenic fusion proteins generated by chromosomal translocations play major roles in
cancer. Among them, fusions between EWSR1 and transcription factors generate …

Purpose: Clear cell sarcoma (CCS) usually arises in the lower extremities of young adults
and is typically associated with at (12; 22) translocation resulting in the fusion of EWS …

Aims Although the morphological assessment of melanoma is generally straightforward,
diagnosis can be especially difficult when the significant morphological and …

The molecular hallmark of angiomatoid fibrous histiocytoma (AFH) is not well defined, with
only six cases with specific gene fusions reported to date, consisting of either FUS‐ATF1 or …

Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to
malignant melanoma but a distinct genetic background including a chromosomal …

Gastroblastoma is a rare distinctive biphasic tumor of the stomach. The molecular biology of
gastroblastoma has not been studied, and no affirmative diagnostic markers have been …

Unlike melanoma, clear cell sarcoma harbors either at (12; 22)(q13; q12) recurrent
translocation, resulting in an EWSR1/ATF1 chimeric gene, or less commonly at (2; 22)(q34; …

Context Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue neoplasm of
intermediate biologic potential and uncertain differentiation, most often arising in the …