Unraveling RNA conformation dynamics in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episode syndrome with solid-state nanopores

S Namani, K Kavetsky, CY Lin, S Maharjan… - ACS …, 2024 - ACS Publications
This study investigates transfer ribonucleic acid (tRNA) conformational dynamics in the
context of MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like …

Tissue-specific apparent mtDNA heteroplasmy and its relationship with ageing and mtDNA gene expression

S Wengert, X Giannoulis, P Kreitmaier, P Kautz… - bioRxiv, 2024 - biorxiv.org
Heteroplasmy in the mitochondrial DNA (mtDNA) accumulates with age, but how much it
occurs in tissues and how it affects function and physiology is not well-studied. Here we …