Molecular mechanisms underlying nucleotide repeat expansion disorders
The human genome contains over one million short tandem repeats. Expansion of a subset
of these repeat tracts underlies over fifty human disorders, including common genetic …
of these repeat tracts underlies over fifty human disorders, including common genetic …
Plant organellar genomes: much done, much more to do
Plastids and mitochondria are the only organelles that possess genomes of endosymbiotic
origin. In recent decades, advances in sequencing technologies have contributed to a …
origin. In recent decades, advances in sequencing technologies have contributed to a …
Graph pangenome captures missing heritability and empowers tomato breeding
Missing heritability in genome-wide association studies defines a major problem in genetic
analyses of complex biological traits,. The solution to this problem is to identify all causal …
analyses of complex biological traits,. The solution to this problem is to identify all causal …
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
Large structural variations (SVs) within genomes are more challenging to identify than
smaller genetic variants but may substantially contribute to phenotypic diversity and …
smaller genetic variants but may substantially contribute to phenotypic diversity and …
[HTML][HTML] The evolution of insecticide resistance in the peach potato aphid, Myzus persicae
The peach potato aphid, Myzus persicae is a globally distributed crop pest with a host range
of over 400 species including many economically important crop plants. The intensive use of …
of over 400 species including many economically important crop plants. The intensive use of …
Short tandem repeats bind transcription factors to tune eukaryotic gene expression
Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
gene expression, yet how they regulate transcription remains unknown. We found that STRs …
On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability
Expansions of simple tandem repeats are responsible for almost 50 human diseases, the
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
majority of which are severe, degenerative, and not currently treatable or preventable. In this …
The QTN program and the alleles that matter for evolution: all that's gold does not glitter
MV Rockman - Evolution, 2012 - academic.oup.com
The search for the alleles that matter, the quantitative trait nucleotides (QTNs) that underlie
heritable variation within populations and divergence among them, is a popular pursuit. But …
heritable variation within populations and divergence among them, is a popular pursuit. But …
Variable tandem repeats accelerate evolution of coding and regulatory sequences
R Gemayel, MD Vinces, M Legendre… - Annual review of …, 2010 - annualreviews.org
Genotype-to-phenotype map** commonly focuses on two major classes of mutations:
single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we …
single nucleotide polymorphisms (SNPs) and copy number variation (CNV). Here, we …
The impact of short tandem repeat variation on gene expression
Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans.
However, genome-wide studies of the effects of STRs on gene expression thus far have had …
However, genome-wide studies of the effects of STRs on gene expression thus far have had …