Given the ever‐increasing toxic exposure ubiquitously present in our environment as well as
emerging evidence that these exposures are hazardous to human health, the current rodent …

This paper, in the form of a frequently asked questions page (FAQ), addresses outstanding
questions about “shadow enhancers”, quasi‐redundant cis‐regulatory elements, and their …

Zebrafish provide a highly versatile model in which to study vertebrate development. Many
recent studies have elucidated early events in the organogenesis of the zebrafish pancreas; …

Bile salt synthesis, secretion into the intestinal lumen, and resorption in the ileum occur in all
vertebrate classes. In mammals, bile salt composition is determined by host and microbial …

Developmental mechanisms regulating gene expression and the stable acquisition of cell
fate direct cytodifferentiation during organogenesis. Moreover, it is likely that such …

Whole-organism chemical screening can circumvent bottlenecks that impede drug
discovery. However, in vivo screens have not attained throughput capacities possible with in …

The transcription factor Pax6 is a developmental regulator with a crucial role in development
of the eye, brain, and olfactory system. Pax6 is also required for correct development of the …

Pancreatic β-cells are an essential source of insulin and their destruction because of
autoimmunity causes type I diabetes. We conducted a chemical screen to identify …

Anderson disease (ANDD) or chylomicron retention disease (CMRD) is a rare, hereditary
lipid malabsorption syndrome associated with mutations in the SAR1B gene that is …

Pluripotent embryonic cells become progressively lineage restricted during development in
a process that culminates in the differentiation of stable organ-specific cell types that perform …