Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Interferons are a group of immunomodulatory substances produced by the human immune
system in response to the presence of pathogens, especially during viral and bacterial …

NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was
identified as a pivotal pathway in mediating inflammatory responses. However, with …

SARS-CoV-2 causes the complex and heterogeneous illness known as COVID-19. The
disease primarily affects the respiratory system but can quickly become systemic, harming …

Background In the phase III POETYK PSO-1 and PSO-2 trials, deucravacitinib, an oral
selective allosteric tyrosine kinase 2 inhibitor, was well tolerated and efficacious over 1 year …

In this in silico study, we conducted an in-depth exploration of the potential of natural
products and antihypertensive molecules that could serve as inhibitors targeting the key …

The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) open reading frame 9b
(ORF9b) antagonizes the antiviral type I and III interferon (IFN) responses and is …

Influenza A (IAV) and SARS-CoV-2 (SCV2) viruses represent an ongoing threat to public
health. Both viruses target the respiratory tract, which consists of a gradient of cell types …