Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes
RWA Mackenzie, BT Elliott - Diabetes, metabolic syndrome and …, 2014 - Taylor & Francis
Type 2 diabetes is a metabolic disease categorized primarily by reduced insulin sensitivity, β-
cell dysfunction, and elevated hepatic glucose production. Treatments reducing …
cell dysfunction, and elevated hepatic glucose production. Treatments reducing …
Inositol pyrophosphates as versatile metabolic messengers
Discovered in 1993, inositol pyrophosphates are evolutionarily conserved signaling
metabolites whose versatile modes of action are being increasingly appreciated. These …
metabolites whose versatile modes of action are being increasingly appreciated. These …
Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain
Summary The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed
by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular …
by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular …
Inositol pyrophosphates: between signalling and metabolism
MSC Wilson, TM Livermore, A Saiardi - Biochemical Journal, 2013 - portlandpress.com
The present review will explore the insights gained into inositol pyrophosphates in the 20
years since their discovery in 1993. These molecules are defined by the presence of the …
years since their discovery in 1993. These molecules are defined by the presence of the …
The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals
Y Moritoh, S Abe, H Akiyama, A Kobayashi… - Nature …, 2021 - nature.com
Circulating phosphate levels are tightly controlled within a narrow range in mammals. By
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
using a novel small-molecule inhibitor, we show that the enzymatic activity of inositol …
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis
Diphosphorylated inositol polyphosphates, also referred to as inositol pyrophosphates, are
important signaling molecules that regulate critical cellular activities in many eukaryotic …
important signaling molecules that regulate critical cellular activities in many eukaryotic …
Inositol pyrophosphates as mammalian cell signals
Inositol pyrophosphates are highly energetic inositol polyphosphate molecules present in
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …
Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling
SB Shears - Journal of cellular physiology, 2018 - Wiley Online Library
Inositol pyrophosphates are small, diffusible signaling molecules that possess the most
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
concentrated three‐dimensional array of phosphate groups in Nature; up to eight …
The inositol pyrophosphate pathway in health and diseases
A Chakraborty - Biological Reviews, 2018 - Wiley Online Library
Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …
Extensive protein pyrophosphorylation revealed in human cell lines
Reversible protein phosphorylation is a central signaling mechanism in eukaryotes.
Although mass-spectrometry-based phosphoproteomics has become routine, identification …
Although mass-spectrometry-based phosphoproteomics has become routine, identification …