Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Decades of neurobiological research have disclosed the diverse manners in which the
response properties of neurons are dynamically modulated to support adaptive cognitive …

Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that are
widely distributed both pre-and post-synaptically in the mammalian brain. By modulating …

The prefrontal cortex (PFC) underlies higher cognitive processes that are modulated by
nicotinic acetylcholine receptor (nAChR) activation by cholinergic inputs. PFC spontaneous …

More than 70% of adolescents report to have smoked a cigarette at least once. At the
adolescent stage the brain has not completed its maturation. The prefrontal cortex (PFC), the …

How is the massive dimensionality and complexity of the microscopic constituents of the
nervous system brought under sufficiently tight control so as to coordinate adaptive …

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-
range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction …