Integration and detection of biochemical assays in digital microfluidic LOC devices

L Malic, D Brassard, T Veres, M Tabrizian - Lab on a Chip, 2010 - pubs.rsc.org
The ambition of lab-on-a-chip (LOC) systems to achieve chip-level integration of a complete
analytical process capable of performing a complex set of biomedical protocols is hindered …

Miniaturization in mass spectrometry

P Mielczarek, J Silberring… - Mass spectrometry …, 2020 - Wiley Online Library
Expectations for continuous miniaturization in mass spectrometry are not declining for years.
Portable instruments are highly welcome by the industry, science, space agencies, forensic …

Characterization of IgG N-glycans employing a microfluidic chip that integrates glycan cleavage, sample purification, LC separation, and MS detection

MA Bynum, H Yin, K Felts, YM Lee, CR Monell… - Analytical …, 2009 - ACS Publications
A novel polymeric microfluidic device with an on-chip enzyme reactor has been developed
for the characterization of recombinant glycoproteins. The enzyme reactor chip packed with …

Preliminary figures of merit for isotope ratio measurements: the liquid sampling-atmospheric pressure glow discharge microplasma ionization source coupled to an …

ED Hoegg, CJ Barinaga, GJ Hager… - Journal of The …, 2016 - ACS Publications
In order to meet a growing need for fieldable mass spectrometer systems for precise
elemental and isotopic analyses, the liquid sampling-atmospheric pressure glow discharge …

Liquid sampling–atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry: preliminary parametric evaluation and figures …

CD Quarles, AJ Carado, CJ Barinaga… - Analytical and …, 2012 - Springer
A new, low-power ionization source for the elemental analysis of aqueous solutions has
recently been described. The liquid sampling–atmospheric pressure glow discharge (LS …

Evaluation of the operating parameters of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) ionization source for elemental mass spectrometry

LX Zhang, BT Manard, SK Kappel… - Analytical and bioanalytical …, 2014 - Springer
The liquid sampling-atmospheric pressure glow discharge (LS-APGD) has been assessed
as an ionization source for elemental analysis with an interdependent, parametric evaluation …

Concomitant ion effects on isotope ratio measurements with liquid sampling–atmospheric pressure glow discharge ion source Orbitrap mass spectrometry

ED Hoegg, RK Marcus, GJ Hager, GL Hart… - Journal of Analytical …, 2018 - pubs.rsc.org
In an effort to understand and improve the accuracy and precision of the liquid sampling-
atmospheric pressure glow discharge (LS-APGD)/Orbitrap system, effects of concomitant …

Development of a multiplexed microfluidic proteomic reactor and its application for studying protein–protein interactions

R Tian, XD Hoa, JP Lambert, JP Pezacki… - Analytical …, 2011 - ACS Publications
Mass spectrometry-based proteomics techniques have been very successful for the
identification and study of protein–protein interactions. Typically, immunopurification of …

Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics

SL Coy, EV Krylov, EG Nazarov, AJ Fornace… - International Journal for …, 2013 - Springer
Electrospray ionization (ESI) is an important tool in chemical and biochemical survey and
targeted analysis in many applications. For chemical detection and identification …

Miniaturized nanoelectrospray interface for coupling capillary electrophoresis with mass spectrometry detection

T Václavek, E Vereshchagina, L Nazareno… - …, 2024 - Wiley Online Library
A miniaturized electrospray interface consisting of a microfluidic nanosprayer and
nanospray module is reported in the presented short communication. The nanosprayer was …