The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer
progression, metastasis and drug resistance. Although there are controversies surrounding …

Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …

Breast cancer is the second common cancer and the leading cause of malignancy among
females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer …

Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer;
however, there are still no drugs targeting CSCs in clinical application. There are several …

Breast cancer remains to be a dreadful disease even with several advancements in
radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by …

Cancer stem cells (CSCs) are subpopulations of tumor cells with the ability to self-renew,
differentiate, and initiate and maintain tumor growth, and they are considered to be the main …

Wnt signaling plays an essential role in the initiation and progression of various types of
cancer. Besides, the Wnt pathway components have been established as reliable …

Abstract Purpose of Review Review current understanding of both canonical and non-
canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of …

Breast cancers have been increasingly recognized as malignancies displaying frequent
inter-and intra-tumor heterogeneity. This heterogeneity is represented by diverse subtypes …