[HTML][HTML] Design strategies for positively charged endolysins: insights into Artilysin development
Endolysins are bacteriophage-encoded enzymes that can specifically degrade the
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …
peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development …
Linker-Improved Chimeric Endolysin Selectively Kills Staphylococcus aureus In Vitro, on Reconstituted Human Epidermis, and in a Murine Model of Skin Infection
F Eichenseher, BL Herpers, P Badoux… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Staphylococcus aureus causes a broad spectrum of diseases in humans and animals. It is
frequently associated with inflammatory skin disorders such as atopic dermatitis, where it …
frequently associated with inflammatory skin disorders such as atopic dermatitis, where it …
Engineered phage with cell-penetrating peptides for intracellular bacterial infections
Salmonella infection poses a critical challenge to global public health, and the situation is
exacerbated by the increasing prevalence of antibiotic resistance. Bacteriophages (phages) …
exacerbated by the increasing prevalence of antibiotic resistance. Bacteriophages (phages) …
[BUCH][B] CPP, cell-penetrating peptides
Ü Langel - 2019 - Springer
The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …
Systemic application of bone-targeting peptidoglycan hydrolases as a novel treatment approach for staphylococcal bone infection
The current standard of treatment for chronic staphylococcal osteomyelitis entails high doses
of antibiotics over the course of several weeks. Biofilm-associated and intracellular …
of antibiotics over the course of several weeks. Biofilm-associated and intracellular …
Engineering of long-circulating peptidoglycan hydrolases enables efficient treatment of systemic Staphylococcus aureus infection
Staphylococcus aureus is a human pathogen causing life-threatening diseases. The
increasing prevalence of multidrug-resistant S. aureus infections is a global health concern …
increasing prevalence of multidrug-resistant S. aureus infections is a global health concern …
MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections
C Roehrig, M Huemer, D Lorgé, F Arn, N Heinrich… - Mbio, 2024 - Am Soc Microbiol
Bacterial infections are a growing global healthcare concern, as an estimated annual 4.95
million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant …
million deaths are associated with antimicrobial resistance (AMR). Methicillin-resistant …
Therapeutic potential of CPPs
Ü Langel - CPP, Cell-Penetrating Peptides, 2023 - Springer
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