Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour
microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) …

Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …

Impressive advances have been made to replicate human physiology in vitro over the last
few years due to the growth of the organ-on-chip (OoC) field in both industrial and academic …

The tumor microenvironment (TME) is the environment around the tumor, including blood
vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix (ECM) …

Cancer thrives in a complex environment where interactions between cellular and acellular
components, surrounding the tumor, play a crucial role in disease development and …

The use of patient-derived tumor tissues and cells has led to significant advances in
personalized cancer therapy and precision medicine. The advent of genomic sequencing …

Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …

Microphysiological systems (MPS), also known as miniaturized physiological environments,
have been engineered to create and study functional tissue units capable of replicating …

The success of immunotherapeutic approaches strictly depends on the immune cells
interaction with cancer cells. While conventional in vitro cell cultures under-represent the …

Rationale: Predicting tumor responses to adjuvant therapies can potentially help guide
treatment decisions and improve patient survival. Currently, tumor pathology, histology, and …