Recent work has identified three distinct classes of viral membrane fusion proteins based on
structural criteria. In addition, there are at least four distinct mechanisms by which viral fusion …

Human respiratory syncytial virus (RSV) is a ubiquitous pathogen that infects everyone
worldwide early in life and is a leading cause of severe lower respiratory tract disease in the …

Abstract Structure–function studies have defined two classes of viral membrane-fusion
proteins that have radically different architectures but adopt a similar overall'hairpin' …

Human respiratory syncytial virus (hRSV) is the most important viral agent of pediatric
respiratory infections worldwide. The only specific treatment available today is a humanized …

Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus of the family
Paramyxoviridae and are unique in that they exhibit a broad species tropism and cause fatal …

We recently described the isolation of a novel paramyxovirus from children with respiratory
tract disease in The Netherlands. Based on biological properties and limited sequence …

The fusion of viral membranes with target-cell membranes is an essential step in the entry of
enveloped viruses into cells, and recent X-ray structures of paramyxoviral envelope proteins …

Enveloped viruses have evolved complex glycoprotein machinery that drives the fusion of
viral and cellular membranes, permitting entry of the viral genome into the cell. For the …

We constructed a human recombinant parainfluenza virus type 3 (rPIV3) that expresses
enhanced green fluorescent protein (GFP) and used this virus, rgPIV3, to characterize PIV3 …

Every enveloped virus fuses its membrane with a host cell membrane, thereby releasing its
genome into the cytoplasm and initiating the viral replication cycle. In each case, one or a …