Nascent pharmacological advancement in adamantane derivatives
The adamantane moiety has attracted significant attention since its discovery in 1933 due to
its remarkable structural, chemical, and medicinal properties. This molecule has a notable …
its remarkable structural, chemical, and medicinal properties. This molecule has a notable …
Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases
B Du, J Ru, Z Zhan, C Lin, Y Liu, W Mao… - European Journal of …, 2024 - Elsevier
Extracellular nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been
identified as a type II transmembrane glycoprotein. It plays a crucial role in various biological …
identified as a type II transmembrane glycoprotein. It plays a crucial role in various biological …
Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and-3 inhibitors
An extensive range of new biologically active morpholine based thiosemicarbazones
derivatives 3a-r were synthesized, characterized by spectral techniques and evaluated as …
derivatives 3a-r were synthesized, characterized by spectral techniques and evaluated as …
Solvent assisted synthesis, DFT, and ADME investigations of soft sulfonylating reagents and novel adamantane constituted sulfonamides: Realization of …
Two novel and soft reagents ([(DBU-Ts)+ Cl-] and [(DBU-Bs)+ Cl-]) were designed,
synthesized and characterized through which two amphiphilic sulfonylated targets were …
synthesized and characterized through which two amphiphilic sulfonylated targets were …
Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors†† Electronic supplementary information (ESI) available. See
Abstract Ectonucleotidases inhibitors (ENPPs, e5′ NT (CD73) and h-TNAP) are potential
therapeutic candidates for the treatment of cancer. Adenosine, the cancer-develo**, and …
therapeutic candidates for the treatment of cancer. Adenosine, the cancer-develo**, and …
The crystal structure of 1-(1-adamantan-1-yl)ethyl-3-(3-methoxyphenyl)thiourea, C20H28N2OS
The crystal structure of 1-(1-adamantan-1-yl)ethyl-3-(3-methoxyphenyl)thiourea, C20H28N2OS
Skip to content Should you have institutional access? Here's how to get it ... De Gruyter € EUR …
Skip to content Should you have institutional access? Here's how to get it ... De Gruyter € EUR …
Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors
Ectonucleotidases inhibitors (ENPPs, e5′ NT (CD73) and h-TNAP) are potential
therapeutic candidates for the treatment of cancer. Adenosine, the cancer-develo**, and …
therapeutic candidates for the treatment of cancer. Adenosine, the cancer-develo**, and …