Stroke in Africa: profile, progress, prospects and priorities

RO Akinyemi, B Ovbiagele, OA Adeniji… - Nature Reviews …, 2021 - nature.com
Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …

Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

[HTML][HTML] Editor's Choice–European Society for Vascular Surgery (ESVS) 2023 clinical practice guidelines on the management of atherosclerotic carotid and vertebral …

R Naylor, B Rantner, S Ancetti, GJ de Borst… - European Journal of …, 2023 - Elsevier
Each section has been revised or rewritten and five new sections added:(i) management of
free floating thrombus (section 4.13),(ii) management of carotid webs (section 4.14),(iii) …

A single-cell atlas of the normal and malformed human brain vasculature

EA Winkler, CN Kim, JM Ross, JH Garcia, E Gil, I Oh… - Science, 2022 - science.org
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Burden of neurological disorders across the US from 1990-2017: a global burden of disease study

VL Feigin, T Vos, F Alahdab, AML Amit… - JAMA …, 2021 - jamanetwork.com
Importance Accurate and up-to-date estimates on incidence, prevalence, mortality, and
disability-adjusted life-years (burden) of neurological disorders are the backbone of …

Thrombus composition and efficacy of thrombolysis and thrombectomy in acute ischemic stroke

P Jolugbo, RAS Ariëns - Stroke, 2021 - Am Heart Assoc
Thrombi retrieved from patients with acute ischemic stroke are highly heterogeneous.
Recent data suggest that thrombus composition may impact on mechanical thrombectomy …

Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Q Tuo, Y Liu, Z **ang, HF Yan, T Zou, Y Shu… - Signal transduction and …, 2022 - nature.com
Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

Advances and challenges in stroke rehabilitation

CM Stinear, CE Lang, S Zeiler, WD Byblow - The Lancet Neurology, 2020 - thelancet.com
Stroke remains a leading cause of adult disability and the demand for stroke rehabilitation
services is growing. Substantial advances are yet to be made in stroke rehabilitation practice …

Pathophysiology of ischemic stroke: role of oxidative stress

S Orellana-Urzúa, I Rojas, L Líbano… - Current …, 2020 - ingentaconnect.com
Stroke is the second leading cause of mortality and the major cause of adult physical
disability worldwide. The currently available treatment to recanalize the blood flow in acute …

Immune responses to stroke: mechanisms, modulation, and therapeutic potential

C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …