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Lipids and lipid derivatives for RNA delivery
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials
Y Shi, H Zhang, S Huang, L Yin, F Wang… - … and Targeted Therapy, 2022 - nature.com
Epigenetics is closely related to cardiovascular diseases. Genome-wide linkage and
association analyses and candidate gene approaches illustrate the multigenic complexity of …
association analyses and candidate gene approaches illustrate the multigenic complexity of …
The interaction of circRNAs and RNA binding proteins: an important part of circRNA maintenance and function
The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene
expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act …
expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act …
History, discovery, and classification of lncRNAs
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
Identifying and characterizing circRNA-protein interaction
Circular RNAs have been identified as naturally occurring RNAs that are highly represented
in the eukaryotic transcriptome. Although a large number of circRNAs have been reported …
in the eukaryotic transcriptome. Although a large number of circRNAs have been reported …
Circular RNAs are miRNA sponges and can be used as a new class of biomarker
Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) that are involved in
transcriptional and posttranscriptional gene expression regulation. The development of …
transcriptional and posttranscriptional gene expression regulation. The development of …
Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression
Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin
protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs …
protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs …
Circles resha** the RNA world: from waste to treasure
J Liu, T Liu, X Wang, A He - Molecular cancer, 2017 - Springer
A new type of RNAs was identified from genes traditionally thought to express messenger or
linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular …
linear ncRNA (noncoding RNA) only. They were subsequently named as circRNAs (circular …
Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma
Z Zhong, M Lv, J Chen - Scientific reports, 2016 - nature.com
Circular RNAs (circRNAs), a kind of non-coding RNAs, have shown large capabilities in
gene regulation. However, the mechanisms underlying circRNAs remain largely unknown …
gene regulation. However, the mechanisms underlying circRNAs remain largely unknown …
Lessons from non-canonical splicing
Recent improvements in experimental and computational techniques that are used to study
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …
the transcriptome have enabled an unprecedented view of RNA processing, revealing many …