Inter-individual variability in drug response, be it efficacy or safety, is common and likely to
become an increasing problem globally given the growing elderly population requiring …

More information about a person's genetic makeup, drug response, multi-omics response,
and genomic response is now available leading to a gradual shift towards personalized …

Drug discovery and development is a time-consuming process that involves identifying,
designing, and testing new drugs to address critical medical needs. In recent years, machine …

Individual variability in drug response (IVDR) can be a major cause of adverse drug
reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic …

Interindividual variability in genes encoding drug-metabolizing enzymes, transporters,
receptors, and human leukocyte antigens has a major impact on a patient's response to …

3. It must behave (act and think) in a rational way: the method that leads the intelligent
system to solve a problem is a formal structured process following the logic. 4. It must obtain …

Interpreting the wealth of rare genetic variants discovered in population-scale sequencing
efforts and deciphering their associations with human health and disease present a critical …

Fluoropyrimidines (FLs)[5-Fluorouracil, Capecitabine] are used in the treatment of several
solid tumors. Dihydropyrimidine dehydrogenase (DPD) is the rate-limiting enzyme for FL …

Variability in genes involved in drug pharmacokinetics or drug response can be responsible
for suboptimal treatment efficacy or predispose to adverse drug reactions. In addition to …

Karolinska Institutet is a medical university encompassing 21 departments distributed across
three departmental or campus groups. Pharmacological research has a long and successful …