[HTML][HTML] Emerging pharmacotherapies for obesity: a systematic review

M Kokkorakis, M Chakhtoura, C Rhayem… - Pharmacological …, 2024 - Elsevier
The history of anti-obesity pharmacotherapies is marked by disappointments, often
entangled with societal pressure promoting weight loss and the prevailing conviction that …

The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and …

AM Gonzalez-Gil, L Elizondo-Montemayor - Nutrients, 2020 - mdpi.com
Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions

AR de Oliveira dos Santos… - International Journal of …, 2021 - mdpi.com
Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce
adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to …

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

Time to transition from a negative nomenclature describing what NAFLD is not, to a novel, pathophysiology-based, umbrella classification of fatty liver disease (FLD)

L Valenzuela-Vallejo, CS Mantzoros - Metabolism, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a definition of a prevalent condition that has
been given a name describing what the disease is not, mainly due to gaps in the …

Effect of various exercise regimens on selected exercise-induced cytokines in healthy people

R Domin, D Dadej, M Pytka, A Zybek-Kocik… - International Journal of …, 2021 - mdpi.com
Different forms of physical activity—endurance, resistance or dynamic power—stimulate
cytokine release from various tissues to the bloodstream. Receptors for exercise-induced …

The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean …

K Stefanakis, M Kokkorakis, CS Mantzoros - Metabolism, 2024 - Elsevier
Incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15–
25% weight loss in many patients, ie, at a rate approaching that achieved with bariatric …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

L Valenzuela-Vallejo, P Chrysafi, M Kouvari… - Metabolism, 2023 - Elsevier
Background The role of metabolic/inflammatory hormonal systems in metabolic dysfunction
associated steatotic liver disease (MASLD) remains to be fully elucidated. Purpose To report …

NAFLD, MAFLD, and beyond: one or several acronyms for better comprehension and patient care

P Portincasa - Internal and Emergency Medicine, 2023 - Springer
The term non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common
type of chronic liver disease. NAFLD points to excessive hepatic fat storage and no evidence …