Role and recent advancements of ionic liquids in drug delivery systems

MK Shukla, H Tiwari, R Verma, WL Dong, S Azizov… - Pharmaceutics, 2023 - mdpi.com
Advancements in the fields of ionic liquids (ILs) broaden its applications not only in
traditional use but also in different pharmaceutical and biomedical fields. Ionic liquids …

Protein immobilization on graphene oxide or reduced graphene oxide surface and their applications: Influence over activity, structural and thermal stability of protein

K Chaudhary, K Kumar, P Venkatesu… - Advances in colloid and …, 2021 - Elsevier
Due to the essential role of biological macromolecules in our daily life; it is important to
control the stability and activity of such macromolecules. Therefore, the most promising route …

[HTML][HTML] Alternative excipients for protein stabilization in protein therapeutics: overcoming the limitations of polysorbates

AJ Castañeda Ruiz, MA Shetab Boushehri, T Phan… - Pharmaceutics, 2022 - mdpi.com
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been
the most widely used excipients for the stabilization of protein therapeutics for years. In …

Expanding the potential role of deep eutectic solvents toward facilitating the structural and thermal stability of α-chymotrypsin

N Yadav, K Bhakuni, M Bisht, I Bahadur… - ACS Sustainable …, 2020 - ACS Publications
Since the introduction of deep eutectic solvents (DESs), numerous reports have surfaced
describing its tunable properties and environmentally benign nature. Due to such favorable …

Cholinium-based ionic liquids as efficient media for improving the structural and thermal stability of immunoglobulin G antibodies

D Dhiman, M Bisht, APM Tavares… - ACS Sustainable …, 2022 - ACS Publications
Among antibody-based biopharmaceuticals, immunoglobulin G (IgG) plays a central role.
However, IgG is a protein and as such easily loses stability, thus compromising its use as an …

Protein aggregation and crystallization with ionic liquids: Insights into the influence of solvent properties

Q Han, SJ Brown, CJ Drummond, TL Greaves - Journal of Colloid and …, 2022 - Elsevier
Ionic liquids (ILs) have been used in solvents for proteins in many applications, including
biotechnology, pharmaceutics, and medicine due to their tunable physicochemical and …

A Vibrant Accelerating Strategic Solvent System for Sustainability and Functionality for Proteins: Unvarying Structure of Stem Bromelain in Hybrid Ionic Fluids

S Nakka, A Sindhu, D Chahar, M Bisht… - ACS Sustainable …, 2023 - ACS Publications
Very recently, a new class of cosolvents, hybrid ionic fluids (HIFs), have been designed by
combining an ionic liquid (IL) and a deep eutectic solvent (DES) with a common anion. The …

A good and bad aggregation: Effect of imidazolium-and cholinium-based ionic liquids on the thermal stability of bovine serum albumin

AA Khachatrian, TA Mukhametzyanov… - Journal of Molecular …, 2023 - Elsevier
The present work describes the effect of imidazolium-and cholinium-based ionic liquids (ILs)
on the thermal stability, binding and aggregation of bovine serum albumin (BSA). The …

Multicolor, injectable BSA-based lanthanide luminescent hydrogels with biodegradability

YY Pei, JT Wang, L Yuan, Y Luo, XY Niu… - International Journal of …, 2023 - Elsevier
Protein hydrogels have attracted increasing attention because of their excellent
biodegradability and biocompatibility, but frequently suffer from the single structures and …

Selective Near-Infrared Blood Detection Driven by Ionic Liquid–Dye–Albumin Nanointeractions

DS Darlington, AN Mahurin, K Kapusta, E Suh… - Langmuir, 2023 - ACS Publications
Due to its abundance in blood, a great deal of research has been undertaken to develop
efficient biosensors for serum albumin and provide insight into the interactions that take …