Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other
moieties, X, and contain the sequence motif or Nudix box, GX5EX7REUXEEXGU. The …

Genomes and their precursor nucleotides are highly exposed to reactive oxygen species,
which are generated both as byproducts of oxygen respiration or molecular executors in the …

The genomes of aerobic organisms suffer chronic oxidation of guanine to the genotoxic
product 8-oxoguanine (oxoG). Replicative DNA polymerases misread oxoG residues and …

Three-dimensional structures of DNA N-glycosylases and N-glycosylase/apyrimidine/
apurine (AP)-lyase enzymes and other critical components of base excision repair (BER) …

The discoveries of nucleotide excision repair and transcription-coupled repair led by Phil
Hanawalt and a few colleagues sparked a dramatic evolution in our understanding of DNA …

The Nudix homology clan encompasses over 80,000 protein domains from all three
domains of life, defined by homology to each other. Proteins with a domain from this clan fall …

7, 8-Dihydro-8-oxoguanine (oxoG) is the most abundant oxidative DNA lesion with dual
coding properties. It forms both Watson–Crick (anti) oxoG:(anti) C and Hoogsteen (syn) …

The quantitative effect of a second damaging mutation on a mutated enzyme may be
additive, partially additive, synergistic, antagonistic, or absent, in the double mutant. Each of …

Hydrogen/deuterium exchange (HDX) methods are widely used for monitoring protein–
ligand interactions. This approach relies on the fact that ligand binding can modulate the …

Oxygen radicals generated through normal cellular respiration processes can cause
mutations in genomic and mitochondrial DNA. Human MTH1 hydrolyzes oxidized purine …