Protein synthesis consumes a large fraction of available resources in the cell. When bacteria
encounter unfavorable conditions and cease to grow, specialized mechanisms are in place …

In response to nutrient deprivation and environmental insults, bacteria conjoin two copies of
non-translating 70S ribosomes that form the translationally inactive 100S dimer. This …

Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress,
where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome …

To survive under conditions of stress, such as nutrient deprivation, bacterial 70S ribosomes
dimerize to form hibernating 100S particles. In γ-proteobacteria, such as Escherichia coli …

The ribosome exit tunnel is an important structure involved in the regulation of translation
and other essential functions such as protein folding. By comparing 20 recently obtained …

Protein synthesis is a major energy-consuming process of the cell that requires the
controlled production,–and turnover, of ribosomes. Although the past few years have seen …

Ribosome hibernation is a universal translation stress response found in bacteria as well as
plant plastids. The term was coined almost two decades ago and despite recent insights …

Assembling and powering ribosomes are energy-intensive processes requiring fine-tuned
cellular control mechanisms. In organisms operating under strict nutrient limitations, such as …

Cells are highly adaptive systems that respond and adapt to changing environmental
conditions such as temperature fluctuations or altered nutrient availability. Such acclimation …

Ribosomes consist of many small proteins and few large RNA molecules. Both components
are necessary for ribosome functioning during translation. According to widely accepted …