Paclitaxel (PTX), the most widely used anticancer drug, is applied for the treatment of
various types of malignant diseases. Mechanisms of PTX action represent several ways in …

BACKGROUND Compelling evidence indicates that paclitaxel kills cancer cells through the
induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression …

Multiple signal transduction pathways are capable of modifying BCL-2 family members to
reset susceptibility to apoptosis. We used two-dimensional peptide map** and …

Janmey, Paul A. The Cytoskeleton and Cell Signaling: Component Localization and
Mechanical Coupling. Physiol. Rev. 78: 763–781, 1998.—The three-dimensional …

Taxol®, an antitumor drug with significant activity, is the first microtubule stabilizing agent
described in the literature. This short review of the mechanism of action of Taxol® …

Microtubules and actin filaments play important roles in mitosis, cell signaling, and motility.
Thus these cytoskeletal filaments are the targets of a growing number of anti-cancer drugs …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Microtubules are intrinsically dynamic polymers, and their dynamics play a crucial role in
mitotic spindle assembly, the mitotic checkpoint, and chromosome movement. We …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …

Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …