The scientific basis of combination therapy for chronic hepatitis B functional cure

SG Lim, TF Baumert, C Boni, E Gane… - Nature Reviews …, 2023‏ - nature.com
Functional cure of chronic hepatitis B (CHB)—or hepatitis B surface antigen (HBsAg) loss
after 24 weeks off therapy—is now the goal of treatment, but is rarely achieved with current …

Immune checkpoint blockade in infectious diseases

MN Wykes, SR Lewin - Nature Reviews Immunology, 2018‏ - nature.com
The upregulation of immune checkpoint molecules, such as programmed cell death protein
1 (PD1) and cytotoxic T lymphocyte antigen 4 (CTLA4), on immune cells occurs during acute …

A global scientific strategy to cure hepatitis B

PA Revill, FV Chisari, JM Block, M Dandri… - The lancet …, 2019‏ - thelancet.com
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …

Adaptive immunity in HBV infection

A Bertoletti, C Ferrari - Journal of hepatology, 2016‏ - Elsevier
During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B

P Fisicaro, V Barili, B Montanini, G Acerbi, M Ferracin… - Nature medicine, 2017‏ - nature.com
Hepatitis B virus (HBV)-specific CD8 T cells are functionally exhausted in chronic hepatitis B
infection, and this condition can be corrected only partially through the modulation of …

Hepatitis B virus persistence and reactivation

Y Shi, M Zheng - Bmj, 2020‏ - bmj.com
Hepatitis B virus (HBV) infection causes chronic hepatitis and has long term complications.
Individuals ever infected with HBV are at risk of viral reactivation under certain …

Liver-mediated adaptive immune tolerance

M Zheng, Z Tian - Frontiers in immunology, 2019‏ - frontiersin.org
The liver is an immunologically tolerant organ that is uniquely equipped to limit
hypersensitivity to food-derived antigens and bacterial products through the portal vein and …

T-cell exhaustion in chronic hepatitis B infection: current knowledge and clinical significance

B Ye, X Liu, X Li, H Kong, L Tian, Y Chen - Cell death & disease, 2015‏ - nature.com
Hepatitis B virus (HBV) infection is the major cause of inflammatory liver disease, of which
the clinical recovery and effective anti-viral therapy is associated with the sustained viral …

[HTML][HTML] Immunopathology of chronic hepatitis B infection: role of innate and adaptive immune response in disease progression

A Khanam, JV Chua, S Kottilil - International Journal of Molecular …, 2021‏ - mdpi.com
More than 250 million people are living with chronic hepatitis B despite the availability of
highly effective vaccines and oral antivirals. Although innate and adaptive immune cells play …

Hepatitis B virus infection

MF Yuen, DS Chen, GM Dusheiko… - Nature reviews Disease …, 2018‏ - nature.com
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic
infection in humans through immune anergy. Currently, 3.5% of the global population is …