[HTML][HTML] Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia
R Okubo, M Okada, E Motomura - Biomolecules, 2024 - mdpi.com
For several decades, the dopamine hypothesis contributed to the discovery of numerous
typical and atypical antipsychotics and was the sole hypothesis for the pathophysiology of …
typical and atypical antipsychotics and was the sole hypothesis for the pathophysiology of …
The Role of Photobiomodulation to Modulate Ion Channels in the Nervous System: A Systematic Review
Z Zhang, Z Zhang, P Liu, X Xue, C Zhang… - Cellular and Molecular …, 2024 - Springer
Photobiomodulation (PBM) is a safe and effective neurotherapy that modulates cellular
pathways by altering cell membrane potentials, leading to beneficial biological effects such …
pathways by altering cell membrane potentials, leading to beneficial biological effects such …
Regulation of NMDAR activation efficiency by environmental factors and subunit composition
M He, LP Wollmuth - Journal of General Physiology, 2025 - rupress.org
NMDA receptors (NMDAR) convert the major excitatory neurotransmitter glutamate into a
synaptic signal. A key question is how efficiently the ion channel opens in response to the …
synaptic signal. A key question is how efficiently the ion channel opens in response to the …
Mechanisms of Action Underlying Conductance-Modifying Positive Allosteric Modulators of the NMDA Receptor
EZ Ullman, RE Perszyk, S Paladugu… - Molecular …, 2024 - Elsevier
ABSTRACT N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors
that mediate a slow, Ca 2+-permeable component of excitatory neurotransmission …
that mediate a slow, Ca 2+-permeable component of excitatory neurotransmission …
[HTML][HTML] Temperature Sensitive Glutamate Gating of AMPA-subtype iGluRs
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that
mediate the majority of excitatory neurotransmission1. iGluRs are gated by glutamate, where …
mediate the majority of excitatory neurotransmission1. iGluRs are gated by glutamate, where …
A GluN2B disease-associated variant promotes degradation of NMDA receptors via autophagy
TM Benske, MP Williams, PP Zhang, AJ Palumbo, T Mu - bioRxiv, 2025 - biorxiv.org
N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory neurotransmission
and their pathogenic variants can lead to proteostasis defects and thus neurological …
and their pathogenic variants can lead to proteostasis defects and thus neurological …
Atomistic Mechanisms of Calcium Permeation Modulated by Q/R Editing and Selectivity Filter Mutations in GluA2 AMPA Receptors
F Heiser, J Biedermann, E Kuru, A Plested, H Sun - bioRxiv, 2024 - biorxiv.org
GluA2 is a key subunit of AMPA receptor ion channels that is abundantly expressed in the
vertebrate brain. Posttranscriptional Q/R editing of GluA2 renders AMPARs nearly …
vertebrate brain. Posttranscriptional Q/R editing of GluA2 renders AMPARs nearly …
Extracellular domains of CATSPERε are essential for CatSper assembly during development and activity modulation in sperm capacitation
JY Hwang, H Wang, G Clouser, JN Oh, SF Finnegan… - bioRxiv, 2024 - biorxiv.org
The flagellar-specific Ca2+ channel CatSper is a multiprotein complex that is critical for
successful fertilization by controlling the sperm Ca2+ signaling in space and time. Large …
successful fertilization by controlling the sperm Ca2+ signaling in space and time. Large …
Neurodevelopmental Disorder Due to a Frameshift Mutation in the GRIN2A Gene: A Case Report and Literature Review
C Xu, ML Wang, WH Ling, JH Tang - 2024 - researchsquare.com
Background: The GRIN2A gene is known to harbor rare mutations that can lead to
neurodevelopmental disorders with diverse phenotypic presentations. This report describes …
neurodevelopmental disorders with diverse phenotypic presentations. This report describes …