Diabetes is the leading cause of severe health complications and one of the top 10 causes
of death worldwide. To date, diabetes has no cure, and therefore, it is necessary to take …

We describe the collection of cohorts together with the analysis plan for an update of the
fracture risk prediction tool FRAX with respect to current and novel risk factors. The resource …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

Abstract The Rotterdam Study is an ongoing prospective cohort study that started in 1990 in
the city of Rotterdam, The Netherlands. The study aims to unravel etiology, preclinical …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Trabecular bone score (TBS) is a gray‐level textural index of bone microarchitecture derived
from lumbar spine dual‐energy X‐ray absorptiometry (DXA) images. TBS is a bone mineral …

Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …

Gut microbiota has been implicated in major diseases affecting the human population and
has also been linked to triglycerides and high-density lipoprotein levels in the circulation …

Background The methods for assessing knee osteoarthritis (OA) do not provide enough
comprehensive information to make robust and accurate outcome predictions. Purpose To …