Role of mitochondria in radiation responses: epigenetic, metabolic, and signaling impacts
D Averbeck, C Rodriguez-Lafrasse - International journal of molecular …, 2021 - mdpi.com
Until recently, radiation effects have been considered to be mainly due to nuclear DNA
damage and their management by repair mechanisms. However, molecular biology studies …
damage and their management by repair mechanisms. However, molecular biology studies …
Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …
JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
Induction of bystander effects by UVA, UVB, and UVC radiation in human fibroblasts and the implication of reactive oxygen species
Radiation-induced bystander effects are various types of responses displayed by
nonirradiated cells induced by signals transmitted from neighboring irradiated cells. This …
nonirradiated cells induced by signals transmitted from neighboring irradiated cells. This …
Fatty acids metabolism: the bridge between ferroptosis and ionizing radiation
Z Yuan, T Liu, H Wang, L Xue, J Wang - Frontiers in Cell and …, 2021 - frontiersin.org
Exposure of tumor cells to ionizing radiation (IR) alters the microenvironment, particularly the
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …
fatty acid (FA) profile and activity. Moreover, abnormal FA metabolism, either catabolism or …
Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation
DM Sridharan, A Asaithamby, SM Bailey… - Radiation …, 2015 - meridian.allenpress.com
During space travel astronauts are exposed to a variety of radiations, including galactic
cosmic rays composed of high-energy protons and high-energy charged (HZE) nuclei, and …
cosmic rays composed of high-energy protons and high-energy charged (HZE) nuclei, and …
Approaches to modeling chemical reaction pathways in radiobiology
P Wardman - International Journal of Radiation Biology, 2022 - Taylor & Francis
Purpose Recent interest in understanding effects of high dose-rate ('FLASH') radiobiology
has prompted a number of groups to model the chemical reactions that might be involved …
has prompted a number of groups to model the chemical reactions that might be involved …
Ionizing radiation-induced cell death is partly caused by increase of mitochondrial reactive oxygen species in normal human fibroblast cells
S Kobashigawa, G Kashino, K Suzuki… - Radiation …, 2015 - meridian.allenpress.com
Radiation-induced cell death is thought to be caused by nuclear DNA damage that cannot
be repaired. However, in this study we found that a delayed increase of mitochondrial …
be repaired. However, in this study we found that a delayed increase of mitochondrial …
The impact of DIDS-induced inhibition of voltage-dependent anion channels (VDAC) on cellular response of lymphoblastoid cells to ionizing radiation
Background: The voltage-dependent anion channels (VDAC) play an essential role in the
cross talk between mitochondria and the rest of the cell. Their implication in cell life and cell …
cross talk between mitochondria and the rest of the cell. Their implication in cell life and cell …
A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays
A Guerreiro, N Chatterton, EM Crabb… - Cancer Nanotechnology, 2019 - Springer
Background A wide range of nanoparticles (NPs), composed of different elements and their
compounds, are being developed by several groups as possible radiosensitisers, with some …
compounds, are being developed by several groups as possible radiosensitisers, with some …
The effect of gamma irradiation on platelet redox state during storage
Background As a method with insignificant adverse effects on in vitro quality of platelet
concentrates (PCs), gamma irradiation is applied to abrogate the risk of transfusion …
concentrates (PCs), gamma irradiation is applied to abrogate the risk of transfusion …