Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders

FV Brozovich, CJ Nicholson, CV Degen, YZ Gao… - Pharmacological …, 2016 - Elsevier
The smooth muscle cell directly drives the contraction of the vascular wall and hence
regulates the size of the blood vessel lumen. We review here the current understanding of …

Urinary bladder contraction and relaxation: physiology and pathophysiology

KE Andersson, A Arner - Physiological reviews, 2004 - journals.physiology.org
The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its
ability to contract over a large length interval and to relax determines the bladder function …

MAP kinases

Z Chen, TB Gibson, F Robinson, L Silvestro… - Chemical …, 2001 - ACS Publications
MAP Kinases | Chemical Reviews ACS ACS Publications C&EN CAS Find my institution Log In
Chemical Reviews ACS Publications. Most Trusted. Most Cited. Most Read Quick View Share …

Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression

AP Burke, FD Kolodgie, A Farb, DK Weber… - Circulation, 2001 - Am Heart Assoc
Background—Subclinical episodes of plaque disruption followed by healing are considered
a mechanism of increased plaque burden. Detailed pathological studies of healed ruptures …

[HTML][HTML] Calponin 1 increases cancer-associated fibroblasts-mediated matrix stiffness to promote chemoresistance in gastric cancer

Y Lu, Z **, J Hou, X Wu, Z Yu, L Yao, T Pan, X Chang… - Matrix Biology, 2023 - Elsevier
The mechanical microenvironment regulated by cancer-associated fibroblasts (CAFs)
influence tumor progression. Chemotherapeutic interventions including 5-Fluorouracil (5-Fu) …

The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity

M Ebisuya, K Kondoh, E Nishida - Journal of cell science, 2005 - journals.biologists.com
ERK MAP kinase signaling plays a pivotal role in diverse cellular functions, including cell
proliferation, differentiation, migration and survival. One of the central questions concerning …

[HTML][HTML] Functional plasticity of CH domains

M Gimona, K D**ovic-Carugo, WJ Kranewitter… - FEBS letters, 2002 - Elsevier
With the refinement of algorithms for the identification of distinct motifs from sequence
databases, especially those using secondary structure predictions, new protein modules …

Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells

R Liu, JP ** - Gene, 2016 - Elsevier
Calponin is an actin filament-associated regulatory protein expressed in smooth muscle and
many types of non-muscle cells. Three homologous genes, CNN1, CNN2 and CNN 3 …

The roles of MAPKs in disease

MC Lawrence, A Jivan, C Shao, L Duan, D Goad… - Cell research, 2008 - nature.com
MAP kinases transduce signals that are involved in a multitude of cellular pathways and
functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate …

Smooth muscle signalling pathways in health and disease

HR Kim, S Appel, S Vetterkind… - Journal of cellular …, 2008 - Wiley Online Library
• Introduction• Mechanisms that regulate LC20 phosphorylation‐Regulation of myosin
phosphatase‐CaMKII• Mechanisms that regulate the access of myosin to actin‐Caldesmon …