The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Organ-on-a-chip systems are miniaturized microfluidic 3D human tissue and organ models
designed to recapitulate the important biological and physiological parameters of their in …

Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of
hepatocyte polarization and maintenance of metabolic function. We here report the …

The liver performs many key functions, the most prominent of which is serving as the
metabolic hub of the body. For this reason, the liver is the focal point of many investigations …

The liver is a central organ in the human body and first line of defense between host and
external environment. Liver response to any external perturbation is a collective reaction of …

Advances in microsystem engineering have enabled the development of highly controlled
models of the liver that better recapitulate the unique in vivo biological conditions. In just a …

In vitro liver models provide essential information for evaluating drug metabolism, metabolite
formation, and hepatotoxicity. Interfacing liver models with other organ models could provide …

Liver disease represents a growing global health burden. The development of in vitro liver
models which allow the study of disease and the prediction of metabolism and drug-induced …

Hepatic in vitro platforms ranging from multi‐well cultures to bioreactors and microscale
systems have been developed as tools to recapitulate cellular function and responses to aid …

Pharmaceutical drugs are necessary to cure or slow down the progression of diseases. The
promising chemical and biological candidates that go through the drug development …