Furin catalyses a simple biochemical reaction—the proteolytic maturation of proprotein
substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and …

A wealth of information has recently become available on the molecular signals that are
required to form and pattern the dentition in the mouse, shedding light on how important …

Cranial neural crest cells are an evolutionary innovation of vertebrates for craniofacial
development and function, yet the mechanisms that govern the cell fate decisions of …

Inappropriate or prolonged inflammation is the main cause of many diseases; for this reason
it is important to understand the physiological mechanisms that terminate inflammation in …

Hair follicle (HF) development is the result of neuroectodermal–mesodermal interactions,
and can be divided into morphologically distinguishable stages (induction, organogenesis …

All ectodermal organs, eg hair, teeth, and many exocrine glands, originate from two adjacent
tissue layers: the epithelium and the mesenchyme. Similar sequential and reciprocal …

Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

The membrane-bound form of Fas ligand (FasL) signals apoptosis in target cells through
engagement of the death receptor Fas, whereas the proteolytically processed, soluble form …

Wnt/β-catenin signaling plays key roles in tooth development, but how this pathway
intersects with the complex interplay of signaling factors regulating dental morphogenesis …

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-
mesenchymal interactions. These processes involve a series of inductive and permissive …