Background Patients with critical illness can lose more than 15% of muscle mass in one
week, and this can have long-term detrimental effects. However, there is currently no …

Critically ill patients often acquire neuropathy and/or myopathy labeled ICU-acquired
weakness. The current insights into incidence, pathophysiology, diagnostic tools, risk …

Background Intensive care unit (ICU)–acquired weakness often develops in patients who
are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU …

Background Physical therapy can prevent functional impairments and improve the quality of
life of patients after hospital discharge. However, the effect of early mobilization on patients …

Acute kidney disease (AKD)-which includes acute kidney injury (AKI)–and chronic kidney
disease (CKD) are highly prevalent among hospitalized patients, including those in …

Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

Background Sepsis and inflammation can cause intensive care unit‐acquired weakness
(ICUAW). Increased interleukin‐6 (IL‐6) plasma levels are a risk factor for ICUAW. IL‐6 …

A substantial number of patients admitted to the ICU because of an acute illness,
complicated surgery, severe trauma, or burn injury will develop a de novo form of muscle …

Background: Pulmonary rehabilitation is recognized as a core component of the
management of individuals with chronic respiratory disease. Since the 2006 American …

Background Survivors of critical illness often experience a multitude of problems that begin
in the intensive care unit (ICU) or present and continue after discharge. These can include …